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The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist II to join a talented and collaborative team to develop cell culture processes for GMP applications.

In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.

KEY RESPONSIBILITIES:

Develop and optimize robust and scalable cell culture processes in ambr250 and 2L bioreactors

Perform pilot scale material generation using 50L, 200L and 500L single use bioreactors

Develop inoculum expansion and master cell bank generation processes

Design and execute small scale and pilot scale depth filtration and centrifugation primary recovery processes

Perform tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities

Provide person-in-plant support at the GMP manufacturing facility

Develop and optimize N-1 perfusion processes as well as intensified fed-batch processes

Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines

Author and review technical reports, GMP campaign summary reports and relevant sections in regulatory filings

Proactively identify and implement opportunities to optimize platform processes and deepen process understanding

Present scientific findings at internal or external conferences

Basic:

Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field, 5 years for M.S., or 7 years for B.S.

Proficient in aseptic techniques

Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250 and 2L bioreactors

Significant experience with perfusion technology, especially Alternating Tangential flow filtration (ATF) at bench and pilot scale

Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts

Strong attention to detail; active and quick learner; able to change courses quickly as needed, raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others

Experienced in technical report authoring and reviewing

Proficient with Microsoft Office software (Word, Excel, and PowerPoint) and statistical modelling software such as JMP

Preferred:

Experience with authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences

Basic knowledge of automation and coding languages (Python, etc.)

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state orlocal law:

• The compensation range described below is the range of possible base pay compensation that the Companybelieves ingood faith it will pay for this role at the timeofthis posting based on the job grade for this position.Individualcompensation paid within this range will depend on many factors including geographic location,andwemay ultimatelypay more or less than the posted range. This range may be modified in thefuture.

• We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick),medical/dental/visioninsurance and 401(k) to eligibleemployees.

• This job is eligible to participate in our short-term incentiveprograms.

Note: No amount of payis considered to bewages or compensation until such amount is earned, vested, anddeterminable.The amount and availability of anybonus,commission, incentive, benefits, or any other form ofcompensation and benefitsthat are allocable to a particular employee remains in the Company's soleandabsolutediscretion unless and until paid andmay be modified at the Companys sole and absolute discretion, consistent withapplicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled.

US & Puerto Rico only - to learn more, visithttps://www.abbvie.com/join-us/equal-employment-opportunity-employer.html

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